在肝脏发育、心血管发育、神经发育和药物毒理学方面建立了人类疾病斑马鱼遗传缺陷和器官发育与损伤再生模型，并开展相应疾病模型和器官发育的分子机制研究，以阐明发育和致病过程中的重要信号通路及其调控因子的变化，从而实现为这些重大疾病进行风险预警、精确诊断、有效治疗和药物的研发提供新思路、新途径和新靶标。建立人类疾病脑出血斑马鱼模型，筛选获得治疗脑出血先导化合物药物1个，并与首都医科大学宣武门医院共同发现临床治疗血栓药物具有很好的治疗脑部血肿（脑出血），目前该药物已在宣武门医院进行临床实验。

研发团队以替代哺乳动物、加快筛选进程、降低实验成本为己任，整合资源，发挥各自优势，对已建立疾病模型进行药理学研究和药效学评价，从而实现为有效的治疗这些疾病提供技术服务和科研支撑，完善器官发育与再生研究领域创新体系，建立人类优生优育检测及肝脏、心血管、神经等器官的相关常见复杂疾病的精准治疗的理论体系。目前已建立了斑马鱼脑出血模型，神经退行性疾病斑马鱼模型，斑马鱼肝脏急性损伤再生模型以及完善的肝脏，神经，免疫和心脏的药物毒理学分析技术。

在人才培养方面，积极完善人才梯度，申报科技创新团队；总结科研成果，申报科研奖励和人才项目，培养出“省杰青”2人次，青年井冈学者2人次，省百千万1人次；获得省部级自然科学一等奖1项，三等奖1项，市厅级科学进步奖1项；发表代表性论文30篇，其中SCI收录20篇，影响因子5以上的10篇，申请获得发明专利4项，与省内外高校科研院所持续开展了科研合作和研究生联合培养，同时鼓励本科生进入实验室，早日接触科研，激发其创新热情，培养其创新能力，将团队优势科研资源融入本科生实践教育，本科生以第一作者或共同一作发表SCI学术论文20余篇，其中2014级生物科学孟云龙同学完成的斑马鱼尾鳍再生相关研究，在美国科学院院刊（PNAS）上发表，并在国内外引起了强烈的反响。

实验室秉持努力创造良好的对外开放环境，建立共享制度，以“开放共享、服务创新”为原则，积极为企业、其他高等院校、科研机构提供服务，包括技术服务、学术交流、客座人员工作环境等，吸引各类专业人才来实验室从事短期或长期科研开发工作。以公益性、非盈利性为原则，建立完善实验室开放长效服务机制，开展技术咨询服务、打造生物医药科普基地等内容。平台积极与当地企业江西省林科龙脑科技股份有限公司和普正药业开展合作，其中与江西省林科龙脑科技股份有限公司开展的天然冰片毒理学研究已完成，证明天然冰片较比合成冰片副作用小，且能有效的缓解肾水肿症状，相关的专利和转化正在实施当中。

实验室在软硬件条件，团队建设，研究水平和业绩各个方面处于省内本行业领域领头羊地位，通过积极与省内各个高校科研院所开展科研合作，推动省内发育生物学学科大力发展，改善我省发育生物学领域在国内薄弱的地位。积极推动省内发育生物学学科发展，在本行业领域处于省内领头，国内一流水准，业绩和水平得到省内外同行一致认可和高度评价。

近3年论文一览

1. Bai, Z., Jia, K., Chen, G., Liao, X., Cao, Z., Zhao, Y., Zhang, C., Lu, H. Carbamazepine induces hepatotoxicity in zebrafish by inhibition of the Wnt/β-catenin signaling pathway. (2021) Environmental Pollution

2. Cao, Z., Su, M., Wang, H., Zhou, L., Meng, Z., Xiong, G., Liao, X., Lu, H. Carboxyl graphene oxide nanoparticles induce neurodevelopmental defects and locomotor disorders in zebrafish larvae (2021) Chemosphere

3. Peng, Y., Li, M., Huang, Y., Cheng, B., Cao, Z., Liao, X., Xiong, G., Liu, F., Hu, C., Lu, H. Bifenazate induces developmental and immunotoxicity in zebrafish (2021) Chemosphere

4. Cao, Z., Meng, Y., Gong, F., Xu, Z., Liu, F., Fang, M., Zou, L., Liao, X., Wang, X., Luo, L., Li, X., Lu, H. Calcineurin controls proximodistal blastema polarity in zebrafish fin regeneration (2021) Proceedings of the National Academy of Sciences of the United States of America, 118 (2)

5. Cheng, B., Zou, L., Zhang, H., Cao, Z., Liao, X., Shen, T., Xiong, G., Xiao, J., Liu, H., Lu, H. Effects of cyhalofop-butyl on the developmental toxicity and immunotoxicity in zebrafish (Danio rerio) (2021) Chemosphere

6. Huang, Y., Chen, Z., Meng, Y., Wei, Y., Xu, Z., Ma, J., Zhong, K., Cao, Z., Liao, X., Lu, H. Famoxadone-cymoxanil induced cardiotoxicity in zebrafish embryos (2020) Ecotoxicology and Environmental Safety

7. Xu, Z., Ni, H., Huang, Y., Meng, Y., Cao, Z., Liao, X., Zhang, S., Guo, X., Lu, H. Effect of fomesafen on the embryonic development of zebrafish (2020) Chemosphere

8. Huang, Y., Ma, J., Meng, Y., Wei, Y., Xie, S., Jiang, P., Wang, Z., Chen, X., Liu, Z., Zhong, K., Cao, Z., Liao, X., Xiao, J., Lu, H. Exposure to Oxadiazon-Butachlor causes cardiac toxicity in zebrafish embryos (2020) Environmental Pollution

9. Cheng, B., Jiang, F., Su, M., Zhou, L., Zhang, H., Cao, Z., Liao, X., Xiong, G., Xiao, J., Liu, F., Lu, H. Effects of lincomycin hydrochloride on the neurotoxicity of zebrafish (2020) Ecotoxicology and Environmental Safety

10. Jia, K., Cheng, B., Huang, L., Xiao, J., Bai, Z., Liao, X., Cao, Z., Shen, T., Zhang, C., Hu, C., Lu, H. Thiophanate-methyl induces severe hepatotoxicity in zebrafish (2020) Chemosphere

11. Xiong, G., Deng, Y., Liao, X., Zhang, J., Cheng, B., Cao, Z., Lu, H. Graphene oxide nanoparticles induce hepatic dysfunction through the regulation of innate immune signaling in zebrafish (Danio rerio) (2020) Nanotoxicology, 14 (5), pp. 667-682.

12. Cheng, B., Zhang, H., Hu, J., Peng, Y., Yang, J., Liao, X., Liu, F., Guo, J., Hu, C., Lu, H. The immunotoxicity and neurobehavioral toxicity of zebrafish induced by famoxadone-cymoxanil (2020) Chemosphere

13. Cao, Z., Huang, Y., Xiao, J., Cao, H., Peng, Y., Chen, Z., Liu, F., Wang, H., Liao, X., Lu, H. Exposure to diclofop-methyl induces cardiac developmental toxicity in zebrafish embryos (2020) Environmental Pollution

14. Cao, Z., He, S., Peng, Y., Liao, X., Lu, H. Nanocurcumin inhibits angiogenesis via down-regulating hif1a/VEGF-A signaling in zebrafish (2020) Current Neurovascular Research, 17 (2), pp. 147-154.

15. Wang, H., Meng, Z., Liu, F., Zhou, L., Su, M., Meng, Y., Zhang, S., Liao, X., Cao, Z., Lu, H. Characterization of boscalid-induced oxidative stress and neurodevelopmental toxicity in zebrafish embryos (2020) Chemosphere

16. Xiong, G., Deng, Y., Cao, Z., Liao, X., Zhang, J., Lu, H. The hepatoprotective effects of Salvia plebeia R. Br. extract in zebrafish (Danio rerio) (2019) Fish and Shellfish Immunology, 95, pp. 399-410.

17 Xiong, G., Deng, Y., Li, J., Cao, Z., Liao, X., Liu, Y., Lu, H. Immunotoxicity and transcriptome analysis of zebrafish embryos in response to glufosinate-ammonium exposure (2019) Chemosphere

18. Wang, H., Zhou, L., Meng, Z., Su, M., Zhang, S., Huang, P., Jiang, F., Liao, X., Cao, Z., Lu, H. Clethodim exposure induced development toxicity and behaviour alteration in early stages of zebrafish life (2019) Environmental Pollution

19. Qiu, L., Jia, K., Huang, L., Liao, X., Guo, X., Lu, H. Hepatotoxicity of tricyclazole in zebrafish (Danio rerio) (2019) Chemosphere, 232, pp. 171-179.

20 Cao, Z., Zou, L., Wang, H., Zhang, H., Liao, X., Xiao, J., Zhang, S., Lu, H. Exposure to diclofop-methyl induces immunotoxicity and behavioral abnormalities in zebrafish embryos (2019) Aquatic Toxicology

20. Wang, H., Zhou, L., Liao, X., Meng, Z., Xiao, J., Li, F., Zhang, S., Cao, Z., Lu, H. Toxic effects of oxine-copper on development and behavior in the embryo-larval stages of zebrafish (2019) Aquatic Toxicology, 210, pp. 242-250.

21 Wang, H., Meng, Z., Zhou, L., Cao, Z., Liao, X., Ye, R., Lu, H. Effects of acetochlor on neurogenesis and behaviour in zebrafish at early developmental stages (2019) Chemosphere, 220, pp. 954-964.

21. Xiong, G., Zou, L., Deng, Y., Meng, Y., Liao, X., Lu, H. Clethodim exposure induces developmental immunotoxicity and neurobehavioral dysfunction in zebrafish embryos (2019) Fish and Shellfish Immunology, 86, pp. 549-558.

近三年项目一览表